LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats
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چکیده
منابع مشابه
Simultaneous quantification of opiates, cocaine, and metabolites in hair by LC-APCI-MS/MS.
A quantitative LC-APCI-MS/MS method for simultaneous measurement of opiates, cocaine, and metabolites in hair was developed and validated. Cocaine and opiates were extracted from pulverized hair via sonication in methanol at 37 degrees C for 3 h. Samples were cleaned up using solid-phase extraction. LC separation was achieved in 20 min with identification and quantification by selected reaction...
متن کاملAPPLICATION NOTE Quantification of Urinary Etheno-DNA Adducts by Column-Switching LC/APCI-MS/MS
Lipid peroxidation induced etheno-DNA adducts are promutagenic and have been suggested to play a causal role in the development of human cancers. Therefore, human biomonitoring of etheno-DNA adducts in urine has been suggested as a potential marker for oxidative stress-related DNA damage. For quantitative determination, a column-switching LC/APCIMS/MS method was developed for simultaneous analy...
متن کاملQuantification of urinary etheno-DNA adducts by column-switching LC/APCI-MS/MS.
Lipid peroxidation induced etheno-DNA adducts are promutagenic and have been suggested to play a causal role in the development of human cancers. Therefore, human biomonitoring of etheno-DNA adducts in urine has been suggested as a potential marker for oxidative stress-related DNA damage. For quantitative determination, a column-switching LC/APCI-MS/MS method was developed for simultaneous anal...
متن کاملInvestigations of carotinoids in Spinach using LC-APCI-MS
The analysis of carotinoids is usually performed by HPLC with UV/VIS detection. Different geometric isomers can be separated using C30 stationary phases [1]. However, the complexity of most matrices makes an unequivocal identification very difficult. For this reason we investigated the use of an ion trap analyzer for the identification of carotinoids in spinach. Since carotinoids are rather non...
متن کاملPharmacokinetics of rosmarinic acid in rats by LC-MS/MS: absolute bioavailability and dose proportionality
Rosmarinic acid (RA), one of the main bioactive compounds of Rosmarinus officinalis L., exhibits diverse pharmacological effects. However, its oral absolute bioavailability and dose proportionality in vivo have not been comprehensively studied. In the present study, a validated LC-MS/MS method was developed for the determination of RA in rat plasma. Pharmacokinetic parameters were obtained foll...
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ژورنال
عنوان ژورنال: Journal of Chromatographic Science
سال: 2014
ISSN: 0021-9665,1945-239X
DOI: 10.1093/chromsci/bmu172